Understanding association of different variables with brca1 2 mutation status n 95 a requires examining multiple perspectives and considerations. Association of different variables with BRCA1/2 mutation status, N=95 a. This review explains the concept of founder effect, then applies it to analyze published Jordanian BRCA variants, and concludes that nine pathogenic (P) and likely pathogenic (LP) BRCA2... Impact of germline BRCA1/2 mutations on response to neoadjuvant ....
We investigated whether germline BRCA1/2 pathogenic variants (PVs) influence treatment response and survival outcomes in breast cancer patients treated with neoadjuvant chemotherapy (NCT). Clinical outcome of breast cancer in carriers of BRCA1 and BRCA2 .... We collected clinical, pathological and genetic data of a cohort 925 BC patients preselected for genetic screening and treated with neoadjuvant or adjuvant chemotherapy, of whom 266 were BRCA carriers.
Overall, 171 women carried a BRCA1 mutation, 95 carried a BRCA2 mutation, and 659 were non-carriers. Breast Cancer Prognosis in Young BRCA1/BRCA2 Mutation Carriers: A .... This perspective suggests that, to investigate the association between overall survival (OS) and DFS (dependent variables) and BRCA mutation status (main independent variable), we constructed two models. Additionally, reduced penetrance BRCA1 and BRCA2 pathogenic variants in clinical ....
Prior studies have suggested the existence of reduced penetrance pathogenic variants (RPPVs) in BRCA1 and BRCA2 (BRCA) which pose challenges for patient counseling and care. Insights into genetic modifiers of breast cancer risk in carriers of. Furthermore, this review presents the overview of known genetic risk modifiers for carriers of BRCA1 and BRCA2 pathogenic variants, their potential impact on risk, and their functional roles. Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy .... In summary, BRCA2 mutations were associated with significantly improved primary chemotherapy response and longer platinum-free durations than were BRCA1 -mutated and wild-type BRCA ovarian cancer patients, whereas BRCA1 mutations had no statistically significant association with primary chemotherapy sensitivity or platinum-free survival ...
BRCA1/2 Mutations and Breast/Ovarian Cancer Risk: A New ... Conducted on large international cohorts, these studies present compelling evidence of the relationship between different BRCA1 and BRCA2 mutations and the varying risks of breast and ovarian cancer. Impact of BRCA mutations, age, surgical indication, and hormone status .... We systematically document and highlight the degree of variations across normal human FT, defining five groups capturing major cellular and molecular changes across various reproductive stages,... An overview of the research progress of BRCA gene mutations in breast ....
In relation to this, bRCA1 and BRCA2 are breast cancer susceptibility genes, and BRCA1/2 gene mutations are associated with an increased risk of breast cancer, with different prevalence in different molecular subtypes.
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