Frontiers Reprogramming Immune Cells For Enhanced Cancer

Understanding frontiers reprogramming immune cells for enhanced cancer requires examining multiple perspectives and considerations. Frontiers | Reprogramming Immune Cells for Enhanced Cancer .... With the advances in the knowledge in the cross-talk between different immune cells and tumor cells, the techniques in cell engineering and drug delivery, and immunotherapies targeting accessory immune cells either ex vivo or in vivo have been intensively studied (Figure 1). Reprogramming Immune Cells for Enhanced Cancer Immunotherapy ... Here, we summarized the central roles of immune cells in tumor progression and regression, and the existing and emerging strategies for different immune cell-based immunotherapies. Cancer cell reprogramming: turning the enemy into an ally. Additionally, by reprogramming tumor cells to actively present antigens and recruit immune cells in vivo, Ascic and colleagues offer an innovative solution to one of the major limitations of current...

Microglial reprogramming enhances antitumor immunity and ... We show that activation of the Rela/Nuclear Factor κB (NF-κB) pathway in microglia promotes melanoma brain metastasis. Targeting this pathway elicits microglia reprogramming toward a proinflammatory phenotype, which enhances antitumor immunity and reduces brain metastatic burden. Frontiers | Metabolic reprogramming in the tumor microenvironment .... Given that T cell stemness can have long-lasting anti-tumor effects in immunotherapy, in this brief review, we summarize the effects of TME changes on T cell stem-cell properties for providing insights into optimizing and enhancing immunotherapy strategies.

Reprogramming Compromised Immune Cells to Fight Cancer. Equally important, in the current study, investigators sought to better understand this process and test ways to turn the macrophages back into healthy anti-tumor cells. Reprogramming cell fates towards novel cancer immunotherapies. Reprogramming technologies that facilitate the engineering of cell types of interest, are emerging as a putative solution to such challenges. Building on this, here we focus on the recent progress being made in reprogramming technologies with respect to the immune system and their potential for clinical applications.

Innovative Strategies of Reprogramming Immune System Cells by Targeting .... We describe the different delivery approaches of CRISPR/Cas9 genome-editing system to different immune system cells in parallel, to study the role of engineering these cells as an immunotherapeutic approach to combat cancer progression. Building on this, orchestrating an immune response to cancer with cellular reprogramming. Our study establishes the foundations for the development of a novel cancer immunotherapy modality that allows in situ reprogramming of cancer cells into tumour-antigen-presenting cells,... Another key aspect involves, cell Fate Reprogramming in the Era of Cancer Immunotherapy.

While efforts in reprogramming and programming individual immune cell identities with fidelity will provide valuable cell sources for cancer immunotherapy, additional approaches take advantage of cellular reprogramming principles to modify cancer cell fate directly.