Understanding gut microbiota derived metabolites promote the differentiation and requires examining multiple perspectives and considerations. Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune .... Metabolites from the gut microbiota such as short-chain fatty acids (SCFAs), tryptophan metabolites (Trps), and bile acid metabolites (BAs) promote the differentiation and function of immune-suppressive cells and inhibit the inflammatory cells. Gut microbiota-derived metabolites in the regulation of host immune ....
Here, we review the role of microbiota-derived metabolites in regulating the functions of different immune cells and the pathogenesis of chronic immune-related inflammatory diseases. Gut microbiota derived bile acid metabolites maintain the homeostasis .... We here summarize recent advances in how BAs and their metabolites maintain gut and systemic homeostasis, including the metabolism of the BAs and their derivatives, the role of BAs and their metabolites in the differentiation and function of immune cells, and the effects of BAs and their metabolites on immune-associated disorders. Gut microbiota-derived metabolites tune host homeostasis fate.
In this review, we elucidate the primary types of gut microbiota-derived metabolites, focusing on those of particular relevance to host homeostasis. The role of gut microbial metabolites in the T cell lifecycle. We will summarize key findings about gut microbial metabolite regulation of various stages of T cell life: thymic development, activation and differentiation, and finally memory and... Microbiota-derived butyrate promotes a FOXO1-induced stemness program ....
The gut microbiome impacts immunity at various levels, including response to immunotherapy. find that metabolic pathways shared across different microbiota constituents, including SCFA synthesis, modulate stem-like tumor-specific CD127+CD8+ T cells in the tumor-draining lymph node and impact control of melanoma. Gut bacteria-derived metabolites and their implications in mental .... Gut bacteria generate various metabolites that can significantly affect brain function and behavior through the microbiota–gut–brain axis.
This article highlights the role of short-chain fatty acids, tryptophan derivatives, bile acids, and neurotransmitter-like metabolites in regulating neuroinflammation, synaptic plasticity, and neuronal signaling. The article also explores the potential ... Gut microbiota is a master regulator of host physiology. Intestinal microbes produce numerous metabolites through primary and secondary metabolic pathways, and many of which are dependent on host diet.
Melanoma Immunity Linked to Gut Metabolites and Diet | Technology Networks. Another key aspect involves, new research has illustrated how metabolites from gut bacteria can improve the function of cancer-fighting immune cells, explaining why patients with a fibre-rich diet and balanced gut bacteria tend to respond better to cancer immunotherapies. Messengers From the Gut: Gut Microbiota-Derived Metabolites ...
In this review, we summarize recent studies in the understanding of the major classes of gut microbiota-derived metabolites, including short-chain fatty acids (SCFAs), bile acids (BAs) and peptidoglycan fragments (PGNs) on their regulatory effects on host functions.
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