When exploring neurotrophin gene therapy for repair of the injured spinal cord, it's essential to consider various aspects and implications. Neurotrophin treatment to promote regeneration after traumatic CNS injury. Here, we will review the effects of various neurotrophins in mediating recovery after injury to the adult spinal cord. Keywords: Axonal guidance, neurotrophin, regeneration, functional recovery, sprouting.
Neurotrophic factors-based therapeutic strategies in the spinal cord .... From another angle, in recent research, transplanted genetically modified adipose-derived mesenchymal stem cells (ADSCs) most frequently have been used to deliver NGF at the injured site of the spinal cord to induce neuronal growth responses and repair it. Thiorphan reprograms neurons to promote functional recovery after ....
Thiorphan is identified as a new and effective drug treatment for spinal cord injury that can be adopted across nervous system disease states in the development of new therapies for human ... Neurotrophins and their role in axonal outgrowth following spinal cord .... We describe the structure and function of the neurotrophins and detail their role as chemotactic and regenerative factors for application following spinal cord injury. Additionally, the potential of gene therapies for spinal cord injury repair: a ....
Currently, there is no cure for traumatic spinal cord injury but one therapeutic approach showing promise is gene therapy. In this systematic review and meta-analysis, we aim to assess the efficacy of gene therapies in pre-clinical models of spinal cord injury and the risk of bias. From another angle, gene therapy, neurotrophic factors and spinal cord regeneration. In this chapter we will review the potential and current limitations of neurotrophic factors and gene therapy, in combination with cellular transplants, for axon regeneration and sprouting in the injured spinal cord. Neurotrophin-3/chitosan inhibits cuproptosis-related genes to enable ....
Objectives: This study investigated the regulatory mechanisms of cuproptosis-related genes (CRGs) in spinal cord injury (SCI) and explored the therapeutic potential of neurotrophin-3 (NT3)-loaded chitosan in promoting functional recovery. In this context, neurotrophic factors, cellular bridges and gene therapy for spinal cord .... An alternative approach that achieves long-term and site-specific delivery of neurotrophic factors to the injured spinal cord is ex vivo gene therapy. The latter approach has been useful for promoting localized, robust axonal growth after spinal cord injury (for review see Tuszynski, 1997). Neurotrophic factors, gene therapy, and neural stem cells for spinal ....
Furthermore, in this review we discuss the use of neural stem cell transplants and neurotrophic factor delivery by gene therapy to improve axonal regeneration in animal models of spinal cord injury. Delayed peripheral treatment with neurotrophin-3 improves sensorimotor .... For example, many groups have shown that delivery of NT3 directly into the central nervous system promotes recovery after spinal cord injury but this often involved invasive routes or gene therapy (Boyce and Mendell, 2014; Petrosyan et al., 2015; Wang et al., 2018).
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