Crystal Structure Of The Trigonal Form Of Human Plasma Retinol Binding We have identified a1120, a high affinity (k(i) = 8.3 nm) non retinoid ligand for rbp4, which disrupts the interaction between rbp4 and its binding partner transthyretin. analysis of the rbp4 a1120 co crystal structure reveals that a1120 induces critical conformational changes at the rbp4 transthyretin interface. This letter highlights our efforts in discovering the first, to our knowledge, non retinoid small molecules that bind to rbp4 at the retinol site and reduce serum rbp4 levels in mice, by disrupting the interaction between rbp4 and transthyretin (ttr), a plasma protein that binds rbp4 and protects it from renal excretion.
Pdf Rcsb Protein Data Bank Rcsb Org Delivery Of Experimentally Crystal structure of retinol binding protein 4 (rbp4) in complex with non retinoid ligand |. 3fmz: identification and characterization of a non retinoid ligand for retinol binding protein 4 which lowers serum retinol binding protein 4 levels in vivo. 212 residues, click to see vast similar structures. * click molecule labels to explore molecular sequence information. madej t, lanczycki cj, zhang d, thiessen pa, geer rc, marchler bauer a, bryant sh. " mmdb and vast : tracking structural similarities between macromolecular complexes. nucleic acids res. 2014 jan; 42 (database issue):d297 303. Crystal structure of retinol binding protein 4 (rbp4) in complex with non retinoid ligand.
Rcsb Pdb 1rlb Retinol Binding Protein Complexed With Transthyretin 212 residues, click to see vast similar structures. * click molecule labels to explore molecular sequence information. madej t, lanczycki cj, zhang d, thiessen pa, geer rc, marchler bauer a, bryant sh. " mmdb and vast : tracking structural similarities between macromolecular complexes. nucleic acids res. 2014 jan; 42 (database issue):d297 303. Crystal structure of retinol binding protein 4 (rbp4) in complex with non retinoid ligand. 3fmz 4psq descriptor retinol binding protein 4, 1 [4 (7 thia 9,11 diazatricyclo[6.4.0.0^{2,6}]dodeca 1(12),2(6),8,10 tetraen 12 yl)piperazin 1 yl] 2 [2 (trifluoromethyl)phenyl]ethanone, 1,2 ethanediol,. This web site. pdbj; yorodumi; pdb 3fmz; cross search:. 215 residues, click to see vast similar structures. * click molecule labels to explore molecular sequence information. madej t, lanczycki cj, zhang d, thiessen pa, geer rc, marchler bauer a, bryant sh. " mmdb and vast : tracking structural similarities between macromolecular complexes. nucleic acids res. 2014 jan; 42 (database issue):d297 303. Here we present 1.5 Å resolution crystal data on human plasma retinol binding protein bound to retinol and fatty acids. these are the highest resolution data available in the protein data bank for this protein.
Structure Of Retinol Binding Protein Showing The Position Of The Four 3fmz 4psq descriptor retinol binding protein 4, 1 [4 (7 thia 9,11 diazatricyclo[6.4.0.0^{2,6}]dodeca 1(12),2(6),8,10 tetraen 12 yl)piperazin 1 yl] 2 [2 (trifluoromethyl)phenyl]ethanone, 1,2 ethanediol,. This web site. pdbj; yorodumi; pdb 3fmz; cross search:. 215 residues, click to see vast similar structures. * click molecule labels to explore molecular sequence information. madej t, lanczycki cj, zhang d, thiessen pa, geer rc, marchler bauer a, bryant sh. " mmdb and vast : tracking structural similarities between macromolecular complexes. nucleic acids res. 2014 jan; 42 (database issue):d297 303. Here we present 1.5 Å resolution crystal data on human plasma retinol binding protein bound to retinol and fatty acids. these are the highest resolution data available in the protein data bank for this protein.
Structure Of Retinol Binding Protein Showing The Position Of The Four 215 residues, click to see vast similar structures. * click molecule labels to explore molecular sequence information. madej t, lanczycki cj, zhang d, thiessen pa, geer rc, marchler bauer a, bryant sh. " mmdb and vast : tracking structural similarities between macromolecular complexes. nucleic acids res. 2014 jan; 42 (database issue):d297 303. Here we present 1.5 Å resolution crystal data on human plasma retinol binding protein bound to retinol and fatty acids. these are the highest resolution data available in the protein data bank for this protein.
Rcsb Pdb 8geu Crystal Structure Of Human Cellular Retinol Binding