Study Specimen Collection Rsv Prevalence Results And Sensitivity By

Study Specimen Collection Rsv Prevalence Results And Sensitivity By Nearly all existing respiratory syncytial virus (rsv) incidence estimates are based on real time polymerase chain reaction (rt–pcr) testing of nasal or nasopharyngeal (np) swabs. adding testing of additional specimen types to np swab rt–pcr increases rsv detection. We quantified rsv detection increase using multiple specimen testing versus nps alone. hospitalized adults aged ≥40 years with acute respiratory illness were prospectively enrolled in 7 us canadian hospitals. nps, saliva, sputa, and acute convalescent sera were collected and tested.

Pdf 1019 Respiratory Syncytial Virus Rsv Diagnoses In Hospitalized Table 1 depicts specimen collection frequency, percent rsv diagnosis by sample type for the entire study population, as well as test sensitivity estimates. Nearly all existing respiratory syncytial virus (rsv) incidence estimates are based on real time polymerase chain reaction (rt–pcr) testing of nasal or nasopharyngeal (np) swabs. adding testing of additional specimen types to np swab rt–pcr increases rsv detection. In this prospective surveillance study spanning 2 respiratory seasons from 2018 to 2020, the addition of paired serology testing, standard of care pcr results, and separate testing of nasopharyngeal and oropharyngeal swabs improved rsv diagnostic yield among hospitalized adults. Rsv detection was 112% higher (95% ci86% 141%) using all specimen types compared to nps alone. saliva had higher sensitivity than nps (61.4% versus 47.2%).

Rsv Sample Collection Copan Diagnostics Inc In this prospective surveillance study spanning 2 respiratory seasons from 2018 to 2020, the addition of paired serology testing, standard of care pcr results, and separate testing of nasopharyngeal and oropharyngeal swabs improved rsv diagnostic yield among hospitalized adults. Rsv detection was 112% higher (95% ci86% 141%) using all specimen types compared to nps alone. saliva had higher sensitivity than nps (61.4% versus 47.2%). Taken together, these results suggest that future studies relying solely on low sensitivity and high specificity tests, could achieve more accurate estimates of rsv disease burden by testing multiple specimen types. We conducted a systematic review and meta analyses to quantify specimen and diagnostic testing based underascertainment of adult rsv infection. methods: embase, pubmed, and web of science were searched (january 2000 december 2021) for studies including adults using comparing >1 rsv testing approach. We conducted a systematic review and meta analyses to quantify specimen and diagnostic testing based underascertainment of adult rsv infection. embase, pubmed, and web of science were searched (january 2000−december 2021) for studies including adults using comparing >1 rsv testing approach. Conclusions rsv detection increased over 100% using four specimen types versus nps alone, suggesting a 2 fold correction factor is appropriate for incidence prevalence studies relying on nps alone. saliva is more sensitive than nps, warranting further study particularly in cardiac patients.